By Wieslaw M. Kazmierski
This publication specializes in new small molecule techniques to strive against viral infections. The chapters describe the invention and improvement from bench in the course of the health facility of rather recently-approved antiviral medicinal drugs and compounds in complicated scientific improvement. prepared through a pandemic (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by means of best educational and commercial professionals within the box, the publication offers a distinct chance to check, comprehend and follow discovery and improvement rules and studying with no the necessity for somebody to analyze, research and synthesize all tremendous sourcing references. themes show off demanding situations and ideas of concerns encountered, offering tremendous event collected over a long time of analysis that may be quite priceless to simple and bench scientists in addition to clinicians as they proceed getting to know and constructing new medicinal drugs and treatments.
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Extra resources for Antiviral Drugs: From Basic Discovery Through Clinical Trials
2004, 36, 1011–1019. ; Fessel, W. ; McLaren, C. Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: a randomized multinational trial. Curr. Med. Res. Opin. 2005, 10, 1683–1692. Malan, D. ; McGrath, D. Efficacy and safety of atazanavir, with or without ritonavir, as part of once-daily highly active antiretroviral therapy regimens in antiretroviral-naive patients. J. Acquir. Immune Defic. Syndr. 2008, 47, 161–167. ; et al. Once-daily atazanavir/ritonavir vs.
No increased incidence of tumors was observed in females at lower doses or in males at any dose. 2 times the human exposure with the two clinical dosing regimens. Based on the nonneoplastic liver findings and the overall lack of genotoxicity, the hepatocarcinogenic effect in high-dose female mice was considered secondary to atazanavir-related cytotoxicity and lacking in clinical relevance because of the relatively high dose and exposure associated with this finding. In rats administered atazanavir at doses of 100, 350, or 1200 mg/kg per day for two years, there were no statistically significant positive trends in the incidence of neoplasms at any dose.
Response rates of plasma HIV1 RNA < 400 copies at week 48 were 86% and 85% on the boosted atazanavir and unboosted atazanavir regimens. There were 3 and 10 patients with virologic failure in the boosted atazanavir and unboosted atazanavir groups, respectively. Plasma lipid elevations were low with both regimens. At 96 weeks, discontinuation rates were similar in both arms, but the response rates were slightly higher in the boosted atazanavir arm, with fewer virological failures than in the unboosted atazanavir arm.
Antiviral Drugs: From Basic Discovery Through Clinical Trials by Wieslaw M. Kazmierski