By Michael J. Parnham (auth.)
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Extra resources for Advantages and Problems with Non-Opioids in Pain Management: Vancouver, Canada, August 19, 1996
Thirty-four workers in an electrode paste plant were monitored for response to exposure (Ovrebo et 3 3 al. 1994). 5 µg/m . 1-Hydroxypyrene was measured in the urine, and PAH-DNA adducts were measured in white blood cells to demonstrate their relationship to the exposure. Results from these workers were compared to two reference control groups: research and development (R&D) workers and nickel refinery workers. Mean values of PAH-DNA adducts in the white blood cells from randomly selected participants in the three groups were only marginally different, with the exception of two smokers in the electrode plant, who had the highest levels.
1981) study is recorded in Table 2-1 and plotted in Figure 2-1. 1 Death No studies were located regarding death in humans after oral exposure to any of the 17 PAHs discussed in this profile. Oral exposure to 120 mg/kg/day benzo[a]pyrene has resulted in decreased survival time in two strains of mice (DBA/2N and AKR/N) whose hepatic aryl hydrocarbon hydroxylase (AHH) activity is not induced by PAHs ("nonresponsive" mice) (Robinson et al. 1975). AHH is a microsomal enzyme believed to be responsible for the metabolism of benzo[a]pyrene.
Similarly, the evaluation of pyrene (241-844 mg/kg) in this study yielded uniformly negative results. Orally administered fluoranthene (400 and 750 mg/kg) did not increase the sister chromatid exchange frequency in mice (Palitti et al. 1986). Gene mutations were not produced in bacteria or yeast in a host-mediated assay in which anthracene, benzo[a]pyrene, chrysene, or fluoranthene were administered to mice by gavage; positive results were produced in bacteria in the same test system in which mice were exposed to benz[a]anthracene and injected intraperitoneally with the bacteria (Simmon et al.
Advantages and Problems with Non-Opioids in Pain Management: Vancouver, Canada, August 19, 1996 by Michael J. Parnham (auth.)