New PDF release: 100 Years of Virology: The Birth and Growth of a Discipline

By A. van Kammen (auth.), Prof. Dr. Charles H. Calisher, Prof. Dr. M. C. Horzinek (eds.)

ISBN-10: 3211833609

ISBN-13: 9783211833605

ISBN-10: 3709164257

ISBN-13: 9783709164259

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Extra resources for 100 Years of Virology: The Birth and Growth of a Discipline

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Certainly, the results obtained by the Giessen team (mainly H. Becht, W. -D. Klenk, M. Orlich, R. Rott, M. F. G. Schmidt, C. Scholtissek and R. T. Schwarz) on structure, production and biological properties of influenza and parainfluenza viral glycoproteins have set a precedent for subsequent investigations with other viruses (for [41)). This includes post-translational modification of the glycoproteins by the different steps of glycosylation, by employment of new glycosylation inhibitors (for [42)), by palmitoylation and myristoylation (for [43]), and by proteolytic cleavage [44].

The development of the Riems FMD concentrated vaccine during the first years after World War II enabled a reduction of the immunising dose from 30 to 5 ml per cattle and the increase in vaccine production on the Isle of Riems, respectively, represented the basis of the annual prophylactic vaccination in the German Democratic Republic (GDR) [43]. "From 1961 to 1965 a pilot plant for the production of FMD-tissue culture vaccines was established" [49]. Great efforts were put into developing a FMD live attenuated vaccine for application in pigs, because it proved impossibe to efficiently immunise swine.

F. G. Schmidt, C. Scholtissek and R. T. Schwarz) on structure, production and biological properties of influenza and parainfluenza viral glycoproteins have set a precedent for subsequent investigations with other viruses (for [41)). This includes post-translational modification of the glycoproteins by the different steps of glycosylation, by employment of new glycosylation inhibitors (for [42)), by palmitoylation and myristoylation (for [43]), and by proteolytic cleavage [44]. In this way the dominant role of these glycoproteins in the initial process of viral replication and their significance as determinants for pathogenicity have been resolved.

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100 Years of Virology: The Birth and Growth of a Discipline by A. van Kammen (auth.), Prof. Dr. Charles H. Calisher, Prof. Dr. M. C. Horzinek (eds.)


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